With Tottenham guaranteed Champions League football and already assured of second-place, Mauricio Pochettino’s side will be playing for pride.
Leicester have also turned things around following Claudio Ranieri’s sacking in February and the Foxes can still finish in the top half of the table.
Craig Shakespeare’s men sit 11th in the table on 32 points – two adrift of 10th-placed Bournemouth.
Having scored in Tottenham’s final match at White Hart Lane last weekend in their win over Manchester United, Harry Kane will be looking to add to his tally.
The England international has 22 league goals to his name, one behind Alexis Sanchez and two off Romelu Lukaku, in the race for the Golden Boot.
Leicester XI: Schmeichel; Simpson, Benalouane, Fuchs, Chilwell; Mahrez, Ndidi, Amartey, Albrighton; Okazaki, Vardy.
Subs: Musa, Kapustka, Slimani, Zieler, Gray, Wasilewski, Moore
Tottenham XI: Lloris, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Sissoko, Dele, Son, Kane
Subs: Vorm, Wimmer, Lesniak, Shashoua, Eriksen, Nkoudou, Janssen